A Comprehensive Pharmacognostic, Phytochemical Description, and Clinical Implementation of Amaranthus viridis

Authors

  • Noor Sabah Jaafar University of Baghdad college of pharmacy
  • Enas J. Kadhim Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

DOI:

https://doi.org/10.31351/vol34iss3pp18-28

Abstract

The pigweed family, Amaranthaceae, includes Amaranthus viridis, popularly known as green amaranth. This herb grows quickly and has an annual lifespan. Traditionally, it has been used to treat anemia, eczema, bronchitis, inflammation, and leprosy. Additionally for respiratory issues, ocular conditions, and asthma.

The phytochemical analysis of Amaranthus viridis L extracts identifies the presence of several categories of biologically active substances (phytochemicals): phenolics, which include flavonoids, tannins, and phenolic acids. Alkaloids, cardiac glycosides, various classes of triterpenoids, and steroids were also found.

Numerous investigations on A. viridis have been conducted to explore its pharmacological range. The majority of research identified laxative, hepatoprotective, analgesic, anti-inflammatory, antitumor, antimicrobial, anti-diabetic, antitumor, wound healing, and antioxidant properties. The goal of the current review of the literature is to give extensive information on the morphological traits, folk usage, phytochemicals, and pharmacological properties of Amaranthus viridis.

How to Cite

1.
Jaafar NS, Enas J. Kadhim. A Comprehensive Pharmacognostic, Phytochemical Description, and Clinical Implementation of Amaranthus viridis. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2025 Sep. 20 [cited 2025 Sep. 20];34(3):18-2. Available from: https://www.bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3171

Publication Dates

Received

2023-11-20

Revised

2024-01-20

Accepted

2024-04-02

Published Online First

2025-09-20

References

Devi G, Sudhakar K, Vasupradaa A, Sravya V, Manasa V, Yasaswini E. Medicinal plants in India and it's antioxidant potential–a review. Revista geintec-gestao inovacao e tecnologias. 2021;11(4):1397-405.

Arêas J, Carlos-Menezes A, Soares R, Caballero B, Finglas P, Toldrá F. Encyclopedia of Food and Health Vol. Amaranth. Oxford: Academic Press; 2016.

3. Hussain MM. A comprehensive review on the phytoconstituents from six species of the genus Amaranthus. Bangladesh pharm. j. 2019;22(1):117-24.

Taylor J, Emmambux M. Products containing other speciality grains: sorghum, the millets, and pseudocereals. Technology of functional cereal products: Elsevier; 2008. p. 281-335.

Jimoh MO, Okaiyeto K, Oguntibeju OO, Laubscher CP. A Systematic Review on Amaranthus. Hortic. Res. 2022;8(3):239.

. Wrigley CW, Corke H, Walker CE. Encyclopedia of grain science: Academic Press.; 2004.

Taia WK, Shehata AA, Ibrahim MM, El-Shamy IM. Vegetative Morphological Variations within Some Egyptian Amaranthus L. Species. Jordan J. Biol. Sci.2021;14(1): 137-46.

Ozimede C, Obute G, Nyananyo B. Morphological and Anatomical Diversity Study on three Species of Amaranthus namely; A. hybridus L., A. viridis L. and A. spinosus L. from Rivers State, Nigeria. J. Appl. SCI. Environ. Manag. 2019;23(10):1875-80.

Singh N, Singh P, Shevkani K, Virdi AS. Amaranth: Potential source for flour enrichment. Flour and breads and their fortification in health and disease prevention: Elsevier; 2019. p. 123-35.

Ahmed SA, Hanif S, Iftkhar T. Phytochemical profiling with antioxidant and antimicrobial screening of Amaranthus viridis L. leaf and seed extracts. Open J. Med. Microbiol. 2013;3: 164-71.

Umar K, Hassan L, Dangoggo S, Maigandi S, Sani N. Nutritional and anti-nutritional profile of spiny amaranth (Amaranthus viridis Linn). Studia Univ. VG, SSV (Life Sciences Series). 2011;21(4):727-37.

Akbar S, Rahman R, Mushtaq A, Azeem MW, Al Mahruqi ZMH. Slender Amaranth: A review on botany, chemistry, pharmacological importance and potential benefits. Int. j. biol. chem. sci. .2017;12: 152-7.

Bayón ND. Identifying the weedy amaranths (Amaranthus, Amaranthaceae) of South America. Adv Weed Sci . 2022;40(2): 11-8.

Amin SFM, Karim R, Yusof YA, Muhammad K. Effects of enzymatic liquefaction, drying techniques, and wall materials on the physicochemical properties, bioactivities, and morphologies of Zinc-amaranth (Amaranthus viridis L.) powders. Int. J. Food Sci. 2021; 2021:13.

Sarker U, Oba S. Nutraceuticals, antioxidant pigments, and phytochemicals in the leaves of Amaranthus spinosus and Amaranthus viridis weedy species. Sci Rep. 2019;9(1):20413-5.

Reyad-ul-Ferdous M, Shahjahan DS, Tanvir S, Mukti M. Present biological status of potential medicinal plant of amaranthus viridis: a comprehensive review. Am J Clin Exp Med. 2015;3(5):12-7.

Holm L, Doll J, Holm E, Pancho JV, Herberger JP. World weeds: natural histories and distribution: John Wiley & Sons; 1997.

Swarnakumari S, SM, MS, Umapoorani aT. Comparative studies on Amaranthus viridus and Amaranthus spinosus. Int. J. Pharm. Sci. Res. 2021;12(10):5612-23.

Omodamiro O, Obinna A. Laxative and antimicrobial activities of ethanolic extract of leaf and roots from Amaranthus viridis on wistar albino rats. J. Med. Plant Res.2017;1:42-6.

Taia WK, Shehata AA, Elshamy EM, Ibrahim MM. Biosystematic studies for some Egyptian Amaranthus L. taxa and their significance in their identification. Taeckholmia. 2020;40(1):85-99.

Xavier JB, Andrade DBd, Souza DCd, Guimarães GC, Resende LV, Guimarães RM. Morphological, chemical and physiological characterization of Amaranthus spp. Seeds. J. Seed Sci.2019;41:478-87.

Nighitha M, Santhi M. The effect of drying on the shelf life of Amaranthus leaves. Int Res J of Eng & Tech. 2019;6(2):219-22.

Emmanuel AM, Roger KK, Toussaint DG, Koffi K. Acute and subacute toxicity of the aqueous extract of Amaranthus viridis (Amaranthaceae) leaves in rats. J Phytopharmacolo. 2018;7(4):366-72.

Srivastava R. HPTLC fingerprint analysis of herbs with nutraceutical potentials: Amaranthus tricolor and Amaranthus viridis. Pharm Innov. 2017;6:324-7.

Kumar BA, Lakshman K, Jayaveera K, Murgan CV, Kumar PA, Kumar RV, et al. Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae. Asian Pac. J. Trop. Med. 2010;3(7):527-30.

Costică M, Stratu A, Costică N. Spontaneous Cormophytes from the Romanian Flora Known as Medicinal Plants in Other Countries? Acta Biologica Marisiensis.4(2):50-5.

Kumari S, Elancheran R, Devi R. Phytochemical screening, antioxidant, antityrosinase, and antigenotoxic potential of Amaranthus viridis extract. Indian J. Pharmacol.2018;50(3):130.

KANERKAR UR. Abortifacient effect of Amaranthus viridis L. aqueous root extract on albino rats. Asian j. biomed. pharm. sci..2016;6(56):13.

Naeem Z, Jabeen K, Iqbal S. Management of ochratoxigenic fungi by phytochemicals of Amaranthus viridis L. J. anim. plant sci. 2022;32(4):1136-42.

Ragasa CY, Austria J, Subosa A, Torres O, Shen C-C. Chemical constituents of Amaranthus viridis Chem. Nat. Compd. 2015;51:146-7.

Jin Y-S, Jin Y, Li C, Chen M, Jin Y, Piao J, et al. Biological Activities of the Whole Grass Extracts from Amaranthus viridis L. Asian J. Chem. 2013;25(13): 7169-72.

OO P. Phenolic compounds composition and in vitro antioxidant activity of Nigerian Amaranthus viridis seed as affected by autoclaving and germination. Measurement: Food. 2022;6: 1-7.

Sarker U, Oba S. Phenolic profiles and antioxidant activities in selected drought-tolerant leafy vegetable amaranth. Scientific Reports. 2020;10(1):18287.

Jaafar NS, Hassan AF, Hamad MN. Evaluation of the Genotoxicity of the Aerial Parts of Iraqi Euphorbia cyathophora on Bone Marrow and Spleen Cells in Mice. Iraqi J. Pharm. Sci. 2023;32(2):41-5.

Swarnakumari S, Sasikala M, Mohan S, Maharaj DU, Kavipriya G. Estimation of phenolic acid and flavonoids in leaves of Amaranthus viridis and Amaranthus spinosus. Res J Pharm Technol. 2021;14(7):3889-95.

Pichaivel M, Dhandayuthapani D, Porwal O, Sharma PK, Manickam D. Phytochemical and pharmacological evaluation Of hydroalcoholic extract Of Amaranthus viridis Linn. Res J Pharm Technol. 2022:2250-69.

Kumar A, Katiyar A, Gautam V, Singh R, Dubey A. A Comprehensive Review on Anti-Cancer Properties of Amaranthus viridis. prevent. 2022;25(26):178-185.

Jaafar NS, Jaafar IS, Noori ZS. Cressa cretica Pharmacognosy, and Pharmacology (A review). Iraqi J. Pharm. Sci .2021;30(2):31-40.

Ahmed OH, Hamad MN, Jaafar NS. Phytochemical investigation of Chenopodium murale (Family: Chenopodiaceae) cultivated in Iraq, isolation and identification of scopoletin and gallic acid. Asian J Pharm Clin Res. 2017;10(11):70-7.

Jaafar NS, Hamad MN, Abbas IS, Jaafar IS. Qualitative phytochemical comparison between flavonoids and phenolic acids contents of leaves and fruits of Melia azedarach (family: Meliaceae) cultivated in Iraq by HPLC and HPTLC. Int J Pharm Pharm Sci. 2016;8(10):242-50.

Darwish RS, Hammoda HM, Ghareeb DA, Abdelhamid AS, Harraz FM, Shawky E. Chemical profiling and identification of anti-inflammatory biomarkers of oriental Thuja (Platycladus orientalis) using UPLC/MS/MS and network pharmacology-based analyses. Nat. Prod. Res. 2021;36(18):4776-80.

42. Jaafar NS, Jaafar IS. Natural Products as A Promising Therapy for SARS COV-2; An Overview. Iraqi J. Pharm. Sci. 2021;30(1):29-40.

House NC, Puthenparampil D, Malayil D, Narayanankutty A. Variation in the polyphenol composition, antioxidant, and anticancer activity among different Amaranthus species. S. Afr. J. Bot.2020;135:408-12.

Chen C, Huang M, Lin K, Hsueh M. The effects of nitrogen application on the growth, photosynthesis, and antioxidant activity of Amaranthus viridis. Photosynthetica. 2022;60(3):420-9.

Devi S. In vivo Protective Role of Amaranthus viridis Extract and Direct Folate Treatment on the Sperms of Swiss Albino Mice. Annals of Clinical & Experimental Metabolism. 2018;3(1):1-6.

Cherian P, Sheela D. Antimicrobial activity of Amaranth Alkaloid against pathogenic microbes. Int. J. Herb. Med. 2016;4(5):70-2.

Kamal AA, Rahman TU, Khan A. Identification, adaptability, phytochemical and nutritional potential of slender amaranth: A review. J Xi'an Shiyou Uni Nat Sci. 2022;18(10):506-16.

Bharathi D, Sahana K, Mahesh C, Babu A, Karthik S, Kumar R, et al. Phytochemical composition and therapeutic effects of Amaranthus viridis Linn: a review. "Int. J. Indig. Med. Plants. 2022:110-3

Silva AD, Ávila S, Küster RT, Dos Santos MP, Grassi MT, de Queiroz Pereira Pinto C, et al. In vitro bioaccessibility of proteins, phenolics, flavonoids, and antioxidant activity of Amaranthus viridis. Plant Foods Hum. Nutr. 2021; 76:478-86.

Ayoka OA, Ojo OE, Imafidon EC, Ademoye KA, Oladele AA. Neuroendocrine effects of aqueous extract of Amaranthus viridis (Linn.) leaf in male Wistar rat model of cyclophosphamide-induced reproductive toxicity. Toxicol. Rep. 2016; 3:608-19.

Sadia S. Qualitative and quantitative phytochemical analysis and antioxidant potential of Amaranthus viridis l. from Pakistan. Proceedings of 54 th The IIER International Conference. 2016:12-6.

Enemchukwu B, Onwuatuegw J, Ofomatah A, Ezeigwe O, Orinya O, Iloanya E, et al. Biochemical and haematological effects of Telfairia occidentalis and Amaranthus viridis Extracts on Anaemic Rats. J. Appl. Sci. 2022;22(3):144-51.

Martemucci G, Costagliola C, Mariano M, D'andrea L, Napolitano P, D'Alessandro AG. Free radical properties, source and targets, antioxidant consumption, and health. Oxygen. 2022;2(2):48-78.

Sunday EA, Gift WP, Boobondah WJ. Phytochemistry and antioxidant activity of Amaranthus viridis L (Green leaf). World J. Adv. Res. Rev. 2021; 12(02): 306–14

Bang J-H, Lee KJ, Jeong WT, Han S, Jo I-H, Choi SH, et al. Antioxidant activity and phytochemical content of nine Amaranthus species. Agronomy. 2021;11(6):1032.

Ying-Shan J, Yonghao X, Manli C, Jinchuan C, Yunzhe J, JIYU P, et al. Antioxidant, Antiinflammatory and Anticancer Activities of Amaranthus viridis L. Extracts. Asian J. Chem.2013;25(16):8901-4.

Salvamani S GB, Shukor MY, Shaharuddin NA, Sabullah MK, Ahmad SA. Anti-HMG-CoA reductase, antioxidant, and anti-inflammatory activities of Amaranthus viridis leaf extract as a potential treatment for hypercholesterolemia. J Evid Based Complementary Altern Med. 2016 ;2016: 1-16

J ALR. Antibacterial activity of Amaranthus viridis L. Int. j. innov. res. Technol.2021;11(7):420-2.

Zahir S, Pal TK, Sengupta A, Biswas S, Bar S, Parveen R. Antibacterial assay of the whole plant ethanolic extract of Amaranthus viridis, Aerva sanguinolenta and Cynodon dactylon against Streptococcus mutans and Lactobacillus acidophillus–An in vitro Microbiological Study. Pharmacognosy Res . 2021;13(4)254-64.

Iqbal MJ, Hanif S, Mahmood Z, Anwar F, Jamil A. Antioxidant and antimicrobial activities of Chowlai (Amaranthus viridis L.) leaf and seed extracts. J Med Plants Res. 2012;6(27):4450-5.

Funde S. Amaranthus Viridis DNA Polymerase, Antioxidant, Antimicrobial and Colon Cancer Study. Spec. J. Med. Res. Health Sci.2019;4(4):56-61

Akbar M, N Sherazi I, Khalil T, S Iqbal M, Akhtar S, N Khan S. Identification of antifungal compounds from slender amaranth. Planta Daninha. 2020; 38:1-5.

Jin Y-S, Li C-M, Xuan Y-H, Jin Y-Z, Chen M-L, Row K-H. Anticancer Activities of Extract from Amaranthus viridis L. Asian J. Chem. 2013;25(14):7857.

Malicdem ACM, Aducal MLO, Cuasay JC, Dalisay DAA, Mendoza AI, Napiza GME, et al. In-Vitro Anti-Proliferative Effect of Flavonoid Extract of Amaranthus viridis (Kolitis) Leaves Against MCF-7 Breast Adenocarcinoma Cell Line. European Journal of Molecular & Clinical Medicine. 2020;7(2):4129-40.

Deepak S. Antioxidant, Anti-inflammatory and Anti-proliferative potential of Amaranthus viridis and Swertia chirata. Plant Biotechnol. J. 2021;7(1):16-25.

Kumar BA, Lakshman K, Jayaveea K, Shekar DS, Khan S, Thippeswamy B, et al. Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats. Exp. Toxicol. Pathol.2012;64(1-2):75-9.

Helen P, Bency BJ. Inhibitory potential of Amaranthus viridis on α-amylase and glucose entrapment efficacy In vitro. Res J Pharm Technol.2019;12(5):2089-92.

Rutika Wakchaure AT, Omkar Zaware, Rahul Lokhande, Ajay B. Shelke. formulation and evluation of herbal antidiabetic tablets. J. emerg. technol. innov. res. 2022;9(6):541-549.

Hasan T, Sultana M. Antidiabetic potency of Bangladeshi medicinal plants. J Ayurvedic Herb Med. 2018;4(1):35-42.

Patel J, Kumar S, Patel H, Prasad A, Iyer S, Vaidya S. Hypoglycaemic and hypolipidaemic potential of aerial parts of Amaranthus viridis (L.) Merr. in streptozotocin induced diabetic rats. Int J Pharm Arch. 2012;1:1-6.

Sarvida F. The Effect of Amaranthus viridis L. on the Blood Sugar Level of Mus musculus. Ascendens Asia j. multidiscip. res. 2019;3(2).

Saravanan G, Ponmurugan P, Sathiyavathi M, Vadivukkarasi S, Sengottuvelu S. Cardioprotective activity of Amaranthus viridis Linn: effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats. Int. J. Cardiol. 2013;165(3):494-8.

Affy Me, Tovi wm-O, Kouakou K. Effect of methanolic extract of Amaranthus viridis leaves on reproductive functions in wistar female rats. J. drug deliv. ther. 2019;9(6-s):119-26.

Sahoo HB, Sahoo SK, Mishra K, Sagar R. Evaluation of the wound-healing potential of Amaranthus viridis (Linn.) in experimentally induced diabetic rats. Int. J. Nutr. Pharmacol. Neurol. Dis.. 2015;5(2):50.

. Bharadwaj A, Sharma A, Singh T, Pathak D, Virmani T, Kumar G, et al. Attenuation of Strychnine-Induced Epilepsy Employing Amaranthus viridis L. Leaves Extract in Experimental Rats. Behav. Neurol. 2023;2023:1-23.

Asha S, Thirunavukkarasu P. Antiurolithiatic activity of Amaranthus viridis on ethylene glycol induced male rat. Inventi Rapid pharmacognosy. 2013;13(4): 1-5.

Thakur* R, RD, Bijay Kumar Das. In vitro phytochemical screening, antioxidant potential and in vivo hepatoprotective and renal protective activity of Amaranthus viridis. J Biochem Biotech 2021;4(4):22-4.

Sundarrajan T, Velmurugan V, Jothieswari D. Hepatoprotective Activity of Ethanol Extracts of Amaranthus viridis Linn on Aflatoxcin B sub 1 Induced Rats. J. Pharm. Sci. Res. 2017; 9(10):1899-902.

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2025-09-20