Study of ATP/GTP binding protein -1 (AGTPBP-1) in Fibrotic Lung Disease with and without COVID-19 Vaccination
DOI:
https://doi.org/10.31351/vol34iss3pp142-147Keywords:
Fibrotic Lung, COVID-19 Vaccination, ATP/ GTP Binding ProteinAbstract
Background : It took less than two months for the severe acute respiratory syndrome that caused by coronavirus disease 2019 to become a palsoemic . ATP/GTP binding protein 1 (AGTPBP1) is responsible for encoding a number of proteins, including cytosolic carboxypeptidase1 (CCP1), which has been investigated in degenerative diseases also has a role in the regulation of polyglutamylation of tubulin.
Patients and methods : A 150 people participated in this study were split into three groups, The first group (G1), served as control group included (50) subjects . Second group (G2) consisted of (50) Fibrotic Lung Disease (FLD) patients without COVD-19 vaccine . Third group (G3) consisted of (50) FLD patients with COVID-19 vaccine . ESR , CRP,LDH, Ferritin ,D-dimer. were measured by enzymatic method . AGTPBP1 levels were measured using the ELISA technique .
Results : Result show highly significant increases in ESR, CRP and LDH levels among three groups . ANOVA descriptive analysis of Ferritin, D-dimers and AGTPBP1 for all studied groups . Show a significant increase in levels of G3 and G2 comparing to G1 . In addition a significant increase found in G3 comparing to G2 .
Conclusion : The present study submits novelty in COVID-19 fields by Focus on role of new parameter such as AGTPBP1 in corona-19 vaccine (Pfizer) that used in Iraq .
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References
Glass DS, Grossfeld D, Renna HA, Agarwala P, Spiegler P, DeLeon J, Reiss AB. Idiopathic pulmonary fibrosis: Current and future treatment. Clin Respir J. 2022;16(2):84-96.
Wong AW, Fidler L, Marcoux V, Johannson KA, Assayag D, Fisher JH, Hambly N, Kolb M, Morisset J, Shapera S, Ryerson CJ. Practical considerations for the diagnosis and treatment of fibrotic interstitial lung disease during the coronavirus disease 2019 pandemic. Chest. 2020;158(3):1069-1078.
Rogowski K, Van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Grau MB, Bec N. A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell. 2010; 12;143(4):564-578.
Parker AL, Kavallaris M, McCarroll JA. Microtubules and their role in cellular stress in cancer. Front Oncol. 2014 ; 18;4:153.
Weitz JI, Fredenburgh JC, Eikelboom JW. A test in context: D-dimer. JACC. 2017;70(19):2411-20.
Facciorusso A, Del Prete V, Antonino M, Neve V, Crucinio N, Di Leo A, Carr BI, Barone M. Serum ferritin as a new prognostic factor in hepatocellular carcinoma patients treated with radiofrequency ablation. J Gastroenterol Hepatol. 2014;29(11):1905-1910.
Lippi G, Favaloro EJ. D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis. Thromb Haemost. 2020;120(05):876-888.
Nagpal P, Guo J, Shin KM, Lim JK, Kim KB, Comellas AP, Kaczka DW, Peterson S, Lee CH, Hoffman EA. Quantitative CT imaging and advanced visualization methods: potential application in novel coronavirus disease 2019 (COVID-19) pneumonia. BJR| Open. 2021;3(1):20200043.
Al-Mendalawi MD. Two Decades in the Journey of Al-Kindy College Medical Journal: Key Barriers, Achievements, and Prospects. KCMJ. 2022;18(1):3-4.
Zyara AM, Aldoori AA, Samawi FT, Kadhim SI, Ali ZA. A relationship study of coronavirus (COVID-19) infection, blood groups, and some related factors in Iraqi patients. Baghdad Sci. J. 2023;20(4 (SI)):1459-1468.
Ismael MK, Aldabagh MA, Rasuol LM. Matrix Metalloproteinase-3 and Tissue inhibitor of metalloproteinase-2 as Diagnostic Markers for COVID-19 Infection. IJS. 2022 Sep 30:3679-3687.
Buti, R. H., El-Yassin, H. D., & Alwan, N. A. S. A. Evaluation of CRP, D-Dimer of clinical significance in Iraqi patients with COVID-19 and associated comorbidities. IJHS.2022; 6(S8): 1505–1513.
Lin Z, Long F, Yang Y, Chen X, Xu L, Yang M. Serum ferritin as an independent risk factor for severity in COVID-19 patients. Journal of infection. 2020;81(4):647-679.
Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, Fan Y, Zheng C. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20(4):425-434.
Shi J, Li Y, Zhou X, Zhang Q, Ye X, Wu Z, Jiang X, Yu H, Shao L, Ai JW, Zhang H. Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study. BMC Med. 2020;18:1-6.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 ;579(7798):270-3.
Han Y, Zhang H, Mu S, Wei W, Jin C, Tong C, Song Z, Zha Y, Xue Y, Gu G. Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study. Aging (Albany NY). 2020;12(12):11245.
Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, Xiong W, Yang D, Chen R, Lu F, Lu Y. COVID-19 with different severities: a multicenter study of clinical features. Am J Respir Crit Care Med. 2020;201(11):1380-1388.
Wu C, Chen X, Cai Y, Zhou X, Xu S, Huang H, Zhang L, Zhou X, Du C, Zhang Y, Song J. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-943.
Düz ME, Balcı A, Menekşe E. D-dimer levels and COVID-19 severity: Systematic Review and Meta-Analysis. Tuberk Toraks. 2020 Dec;68(4):353-360.
Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y, Li B, Song X, Zhou X. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J Clin Virol. 2020;127:104370.
Mohammed SK, Taha MM, Taha EM, Mohammad MN. Cluster analysis of biochemical markers as predictor of COVID-19 severity. Baghdad Sci. J. 2022;19(6 (Suppl.)):1423-1429.
Al-Mendalawi MD. The Scientific Contribution of the Al-Kindy College Medical Journal to the World Literature on the COVID-19 Pandemic. KCMJ. 2023;19(1):1-2.
Al-Humairi RM, Muhsin HY, Ad’hiah AH. Severity of Coronavirus Disease 19: A Profile of Inflammatory Markers in Iraqi Patients. MJMHS. 2022;18(1).
Al-Mamoori HS, Ahmed MH, Al-Nafie TY, Al-Attar Z. Assessment of the Level of Protein C in Hospitalized Iraqi Patients with COVID-19 and its Correlation with Hematological and Inflammatory Markers. Open Access Maced J Med Sci. 2022;10(A):817-823.
Jasim RZ. Biochemical Action of Vaccines in Iraqi Patients with COVID-19 Infection. Baghdad Sci. J. 2023;20(4 (SI)):1469-1479.
Hamid MK. Impact of COVID-19 Vaccine on Hearing Status of Young Ages (Medical College Students as a Sample). Baghdad Sci. J. 2023;20(4 (SI)):1498-1506.
Kwak HJ, Gil M, Chae HS, Seok J, Soundrarajan N, Saha SK, Kim A, Park KS, Park C, Cho SG. Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma. J Pers Med. 2020;10(4):263.
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