Design, Development, and Optimization of Spanlastics for Delivery of Rizatriptan Benzoate
DOI:
https://doi.org/10.31351/vol34iss4pp125-140Keywords:
Cremophor EL 40, Rizatriptan Benzoate, Nanovesicles , Span® 60 , Spanlastics , Box-Behnken designAbstract
Spanlastics are nanovascular drug delivery systems that use surfactants, including hydrophilic and hydrophobic medicines . Spanlastics enhance the ability of medicines to enter the body and provide a continuous release over extended periods . These vesicles possess a high degree of elasticity and flexibility , enabling to improve the transportation of medications through different methods of administrations . Box-behnken design was utilized to establish a relationship between the formulation parameters, specifically the amount of Span 60 , cremophor EL 40 and sonication time and important quality attributes , namely particle size , polydispersity index (PDI) and entrapment efficiency (EE%) . The spanlastic formulations were developed using response surface central composite design and formulated using an ethanol injection . The developed using response surface central composite design and formulated using an ethanol injection . The formulations were analyzed to identify the optimal formula with a tiny particle size , lower PDI and a high EE%. The optimized formula underwent additional analysis using zeta potential measurement in-vitro release profile , Fourier Transform Infrared (FTIR) Analysis , Field Emission Scanning Electron Microscopy (FESEM) ,Differential Scanning Calorimetry Analysis (DSC) and X-ray Diffraction Analysis (XRD) .The improved formulation exhibited a particle size of (84,98)nm, a PDI of 0.1993 and an EE% of (53.69)% . There is a little discrepancy between the observed and predicated values . The zeta potential was - 22. 37 . The optimum formula showed an appropriate release of 88.5% over 8 hr . The compatibility analysis demonstrated that RNB is compatible with the other excipients .Analysis of the vesicle shape revealed that it was nearly spherical . Furthermore , the drug molecule was seen to exist in an amorphous condition within spanlastic formula . In summary , the result demonstrated that spanlastic have the capacity to serve as a carrier for medicine delivery systems .
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References
Alhammid SN, Kassab HJ, Hussein, LS, Haiss MA, & Alkufi, Hk. Spanlastics Nanovesicles: An Emerging and Innovative Approach for Drug Delivery. Maaen Journal for Medical Sciences. 2023; 2(3):11-27. https:// doi.org/10.55810/2789-9136.1027 .
Chauhan MK, & Verma A. Spanlastics future of drug delivery and argeting . Verma et al. World Journal of Pharmaceutical Research.2017; 6(2): 429-436. https://doi.org/10.20959/wjpr201712-9726
Ali MM , Shoukri R A, & Yousry C. Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation. Drug Delivery and Translational Research. 2022;13(4):1153–1168. https://doi.org/10.1007/s13346-022-01285-5.
Salih OS, & Al-Akkam E J. Preparation, In vitro, and Ex vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery. Iraqi Journal of Pharmaceutical Sciences.2023; 32(3):71–84. https://doi.org/ 10.31351/vol32iss3pp71-84
Rajab NA& Jawad MS. Impact of Lipid Type and Ratio in Rizatriptan Benzoate Nanostructured Lipid Carrier. International Journal of Drug Delivery Technology.2023;13(1), 112–119. https: //doiorg/10.25258/ ijddt13. 1. 17
Hadi AS, & Ghareeb MM. Rizatriptan Benzoate Nanoemulsion for Intranasal Drug Delivery: Preparation and Characterization. International Journal of Drug Delivery Technology. 2022; 12 (2), 546–552. https://doi.org/ 10.25258/ijddt.12.2.14 .
Singh O, Sharma S, Naagar M, Maity MK & Kumar Maity M. Eletriptan as treatment option for acute migraine. In International Journal of Innovations & Research Analysis (IJIRA). 2022; 2(3): 11-26. https:// www .researchgate.net/publication/364657249
Agha OA, Girgis GN. S, El-Sokkary M, & Soliman O.Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study. International Journal of Pharmaceutics. 2023; 11(7): 6. https://doi.org/ 10.55 810 /2789-9136.102.
Abbas IK& Abd-AlHammid, SN. Design, Optimization and Characterization of Self-Nano emulsifying Drug Delivery Systems of Bilastine. Iraqi Journal of Pharmaceutical Sciences. 2023; 32: 164–176. https://doi.org /10.31351/vol32issSuppl.pp164-176 .
Ali SK & Al-Akkam E J. Bilosomes as Soft Nanovesicular Carriers for Ropinirole Hydrochloride: Preparation and In- vitro Characterization. Iraqi Journal of Pharmaceutical Sciences .2023 ;32: 177–187. https://doi. org/ 10. 31351 /vol32issSuppl.pp177-187 .
Salih Z T & Al- Gawhari F Improvement of Entrapment and Ocular Permeability of Ganciclovir Nano structured Lipid Carriers Using Various Conditions of Preparations. International Journal of Drug Delivery Technology. 2023; 13(1): 341–346. http://dx.doi.org/10.25258/ijddt.13.1.55.
Mahal R.K& Al-Gawhari F . Design, Development and Optimization of Solid Lipid Nanoparticles for Ocular Delivery of an Antifungal Agent. IJDDT. 2023; 13(1: 327-339. DOI: 10.25258 /ijddt.12.4.36
Salih OS, & Al-Akkam EJ. Preparation, In vitro, and Ex vivo Evaluation of Odansetron Loaded Invasomes for Transdermal Delivery. Iraqi Journal of Pharmaceutical Science. 2023; 32(3): 71–84. https://doi.org/10 .31351/vol32iss3pp71-84 .
Mahmood AA, &Alhammid SNA. Preparation and Ex-Vivo Evaluation of Stabilized Cefdinir Nano suspension. Pakistan Journal of Medical and Health Sciences. 2022; 16(12): 789–794. https://doi.org/10. 53350/pjmhs20221612789 .
Rashid AM &Abd-Alhammid SN. Formulation and characterization of itraconazole as nano suspension dosage form for enhancement of solubility. Iraqi Journal of Pharmaceutical Sciences. 2019; 28(2): 124–133. https:// doi.org/10.31351/vol28iss2pp124-133.
Saad A & Sabri L. Study The Variables Affecting Formulation of Ethylcellulose -based Micro sponges loaded with Clobetasol. Iraqi Journal of Pharmaceutical Sciences. 2023; 32: 225–234. https://doi.org/10.31351 /vol32issSuppl.pp225-234.
Atiyah Altameemi KK, & Abd-Alhammid SN. Anastrozole Nanoparticles for Transdermal Delivery through Microneedles: Preparation and Evaluation. Journal of Pharmaceutical Negative Results. 2022; 13(3): 974–980. https://doi.org/10.47750/pnr.2022.13.03.152.
Salih OS, Jasim E, Salih OS& Al-Akkam E J. Review Article Invasomes as a Novel Delivery Carrier for Transdermal Delivery: Review Article Citation. In Medicon Pharmaceutical Sciences. 2022; 2(3) :23-29. https ://www.researchgate.net/publication/371951443.
Tamer MA, & Kassab HJ. The development of a brain targeted mucoadhesive amisulpride loaded nanostructured lipid carrie. Farmacia 2023; 71(5): 1032–1044. https://doi.org/10.31925/ farmacia.2023.5.18
Talal Sulaiman, & Rajab NA. Soluplus and solutol HS-15olmesartan medoxomil nanomicelle based oral fast dissolving film; in vitro and in vivo characterization. Faramacia. 2024; 72, 4. https:// doi.org /10.31925 /farmacia.2024.4.7.
Jassim BM, & Al-Khedairy EBH. Formulation and in vitro /in vivo Evaluation of Silymarin Solid Dispersion-Based Topical Gel for Wound Healing. Iraqi Journal of Pharmaceutical Sciences. 2023; 32: 42–53. https: //doi.org/10.31351/vol32issSuppl.pp42-53
Bhardwaj P, Tripathi P, Pandey S, Chaurasia D, & Ramchandra P P. Tailored Non-ionic Surfactant Vesicles of Cyclosporine for the Treatment of Psoriasis: Formulation, Ex-Vivo and In-Vivo investigation -Application of Box-Behnken Design. Advanced Materials Science and Technology. 2023; 5(2): 0–0. http://dx.doi.org/10. 37155/2717-526X-0502-2 .
Owodeha-Ashaka K, Ilomuanya MO, Iyire A. Evaluation of sonication on stability-indicating properties of optimized pilocarpine hydrochloride-loaded niosomes in ocular drug delivery. Progress in Biomaterials. 2021;10(3):207-220. doi: 10.1007/s40204-021-00167-2.
Iskandarsyah I, Masrijal CDP, &Harmita H. Effects of sonication on size distribution and entrapment of lynestrenol transferosome. International Journal of Applied Pharmaceutics. 2020; 12(1): 245–247. https://doi. org/10.22159/ijap.2020.v12s1.FF053 .
Chen X, & Wang T. Preparation and characterization of atrazine-loaded biodegradable PLGA nanospheres. Journal of Integrative Agriculture. 2019 ;18(5), 1035–1041. https://doi.org/10.1016/ S2095-3119(19)62613-4
Jassem NA, &Alhammid SNA. Ex vivo permeability study and in vitro solubility characterization of oral Canagliflozin self-nanomicellizing solid dispersion using Soluplus®as a nanocarrier. Acta Marisiensis - Seria Medica .2024 ;70(2), 42–49. https://doi.org/10.2478/amma-2024-0011
Badria F &Mazye E. Formulation of nanospanlastics as a promising approach for improving the topical delivery of a natural leukotriene inhibitor (3-acetyl-11-keto-β-boswellic acid): Statistical optimization, in vitro characterization, and ex vivo permeation study. Drug Design, Development and Therapy. 2020; 14, 3697–3721. https://doi.org/10.2147/DDDT.S265167
Zeng L, Xin X, & Zhang Y. Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant. RSC Advances. 2017; 7(32), 19815–19827. http:// doi.org/10.1039/C6RA27096D
Sailaja AK. Formulation and Evaluation of Aspirin Nanosuspension Using Probe Sonication Method. International Journal of Clinical Case Reports and Reviews. 2023; 14(1):01–04. https://doi.org/10.31579 /2690-4861/314
Mazyed EA, Helal DA, Elkhoudary MM, Abd Elhameed AG & Yasser M. Formulation and optimization of nanospanlastics for improving the bioavailability of green tea epigallocatechin gallate. Pharmaceuticals. 2021; 14(1): 1–30. https://doi.org/10.3390/ph14010068 .
Badria FA, Fayed HA, Ibraheem AK. Formulation of sodium valproate nanospanlastics as a promising approach for drug repurposing in the treatment of androgenic alopecia. Pharmaceutics. 2020;12(9):1–27. https://doi.org/10.3390/pharmaceutics12090866 .
Girotra P, Singh SK. Multivariate Optimization of Rizatriptan Benzoate-Loaded Solid Lipid Nanoparticles for Brain Targeting and Migraine Management. AAPS PharmSciTech. 2017; 18(2):517-528. doi: 10.1208/ s12249 - 016-0532-0.
Nair AB, Shah J, Jacob S, Al-Dhubiab BE, Patel V, Sreeharsha N. Development of mucoadhesive buccal film for rizatriptan: In vitro and in vivo evaluation. Pharmaceutics. 2021;13(5) :7-12. https://doi.org/10.3390/ pharmaceutics13050728 .
Salve P, Bali N. Fabrication and optimization of buccal film comprising rizatriptan benzoate loaded solid lipid nanoparticles for improved ex vivo permeation. 2019; 9:636–48. https://doi.org/10.1016/ j.matpr.2015.10.067.
Khan MI, Madni A, Ahmad S, Mahmood MA, Rehman M, Ashfaq M. Formulation design and characterization of a non-ionic surfactant based vesicular system for the sustained delivery of a new chondroprotective agent. Brazilian Journal of Pharmaceutical Sciences.2015;51: 607-615. https://doi.org/10.1590/S1984-825020150 00300012 .
Mahmood AAA., &Alhammid SNA.Preparation and Ex-Vivo Evaluation of Stabilized Cefdinir Nano suspension. Pakistan Journal of Medical and Health Sciences .2022; 16(12), 789–794. https:// doi.org/ 10.533 50/pjmhs20221612789
Tamer, MA, & Kassab HJ. Optimizing Intranasal Amisulpride Loaded Nanostructured Lipid Carriers: Formulation, Development, and Characterization Parameters. Pharmaceutical Nanotechnology.2024; 12:1-15. https://doi.org/10.2174/0122117385301604240226111533
Abdullah T&Al-Kinani K. Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia. 2024; 71: 1–12. https://doi. org/10.3897/pharmacia. 71.e11 5330 .
Neamah MJ, & Al-Akkam, EJM. Preparation and characterization of vemurafenib microemulsion based hydrogel using surface active ionic liquid. Pharmacia .2024;71:1–9. https://doi.org/ 10.3897/pharmacia. 71.e111178
Soliman MA, Ibrahim HK, Nour SA. Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation, in vitro, and in vivo evaluation. Pharmaceutical Development and Technology. 2021; 16; 26(3):302-15. https://doi.org/10.1080/10837450.2020. 1869982 .
Rajab NA & Jawad MS. Preparation and Evaluation of Rizatriptan Benzoate Loaded Nano structured Lipid Carrier Using Different Surfactant/Co-Surfactant Systems. International Journal of Drug Delivery Technology.2023; 13(1): 120–126. https://doi.org/10.25258/ijddt.13.1.18
Hana YK, Faudoneb SN, Zittob G, Bonafedea SL, Rosascoa MA, Segalla AI. Physicochemical Characterization of Physical Mixture and Solid Dispersion of Diclofenac Potassium with Mannitol. Journal of Applied Pharmaceutical Science. 2017;7(1):204-8. https://dx.doi.org/ 10.7324/ JAPS.2017.70130 .
Frank D, Schenck L, Koynov A, Su Y, Li Y, Variankaval N. Optimizing solvent selection and processing conditions to generate high bulk-density, coprecipitated amorphous dispersions of posaconazole. Pharmaceutics. 2021;13(12): 17-20. https://doi.org/10.3390/pharmaceutics13 122017 .
Chaudhari P, Kolhe S & More, D. Formulation Development Studies of Rizatriptan Benzoate Fast Disintegrating Tablet. Research journal of pharmaceutical biological and chemical sciences. 2011; 4(6) :176-186.
Ahmed EM, Nabil SR, Faten F, Mohamed NS. Bilosomes as a novel carrier for the cutaneous delivery for dapsone as a potential treatment of acne: Preparation, characterization and in-vivo skin deposition. J Liposome Res .2020; 30(1):1-11. https://doi.org/10.1080/08982104.2019.1577256 .
Singh A, Ubrane R, Prasad P, Ramteke S. Preparation and Characterization of Rizatriptan Benzoate Loaded Solid Lipid Nanoparticles for Brain Targeting. Materials Today: Proceedings. 2015;2(9):4521–43. https://doi .org/10.1016/j.matpr.2015.10.067 .
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